Eric Burguière

Tenured Scientist, Ph.D.
ICM ­ Brain & Spine Institute – Room 3029 – Pitié-Salpêtrière Hospital – 47, Bd de l’Hôpital 75013 Paris
+33 1 57 27 44 25
Principal Investigator in charge of the Animal models & Optogenetics program

Eric Burguière is working with mouse models of compulsive behaviors in the BEBG team. During his PhD thesis (obtained from University Paris 6 in December 2006), he first learned to study and analyze mutant mice behavior by designing paradigms to study motor adaptation. Then, during his post-doctoral period in the Graybiel laboratory at the Massachusetts Institute of Technology (2007-2012), he studied mouse models of disorders affecting motor execution as Parkinson disease and OCD-spectrum disorder. He use and develops different methodology such as  multi-unit electrophysiological recordings and optogenetics technology to better probe and understand the pathophysiology of these disorders (Burguiere et al., Science, 2013).


5 Main publications

E. Burguière, P. Monteiro, L. Mallet, G. Feng G, A.M. Graybiel
Striatal circuits, habits, and implications for obsessive-compulsive disorder.
Curr Opin Neurobiol. (2015) Feb;30:59-65.

C. Schreiweis*, U. Bornschein*, E. Burguière, …, S. Pääbo, W. Enard W§, A.M. Graybiel§.
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance.
Proc Natl Acad Sci U S A. (2014) Sep 30;111(39):14253-8.

E. Burguière, P. Monteiro, G. Feng, AM. Graybiel.
Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors.
Science. (2013) Jun 7;340(6137):1243-6.

E. Burguière, A. Arabo, F. Jarlier, C. I. De Zeeuw, L. Rondi-Reig.
Role of the cerebellar cortex in conditioned goal-directed behavior.
J Neurosci. (2010) Oct;30(40):13265-13271.

E. Burguière, A. Arleo, C.I. De Zeeuw, A. Berthoz, L. Rondi-Reig.
Spatial navigation impairment in mice lacking LTD: a motor adaptation deficit?
Nat Neurosci. (2005) Oct;8(10):1292-4.


For the complete list please see:



2014 Prize attributed by French Psychiatry Society for the 3rd best scientific article of the year.
2007 Prize attributed by French Neuroscience Society for the best Neuroscience Thesis of the year.
2005 Prize attributed by Lilly Institute for the PhD work accomplished.



2013 Awarded by FRM Foundation for 2 years of funding as a research scientist.
2012 Awarded by FondaMental Foundation for a 1 year postdoctoral fellowship.
2010 Awarded by Simons Foundation for a 2 years postdoctoral fellowship.
2007 Awarded by EMBO for a 2 years postdoctoral fellowship.
2006 Awarded by FENS (2004) and MCCS (2006) to attend the FENS forums.
Awarded by CELEST program to attend the ICCNS ’06 in Boston.
2004 Awarded by Hertie-Institute to attend a conference in Tuebigen.
Awarded by Ile de France Council to collaborate with IRRCS
2002 Awarded by University Paris 6 for pursuing a 3 years PhD project.


Selected Conference Speaker Invitations

Inaugural conference for the “One day in the heart of the Parisians hospitals” event, Paris.
Conference at the Annual Cerebrovascular Disease Society meeting, Paris.

Inaugural lecture of the French Association for Biological Psychiatry meeting (AFPBN), Paris.
Conference in Pierre et Marie Curie University (Paris 6), invited by P. Faure, Paris.
Conference at Psychiatric Disease and Animal Models symposium, Paris 8 University, St-Denis.

Symposium at the Society of Biological Psychiatry meeting, San Francisco, USA.
Symposium at the French Psychiatric Society, Nice, France.
Seminar at Mayo Clinic, invited by Dr. Kendall Lee, Rochester, USA.
Seminar at the Neurocentre Magendie, invited by Dr. Etienne Coutureau, Bordeaux, France.

Seminar at Brain and Spine Institute, Hospital La Salpétrière, Paris, France.

Seminar at Rafael Fernandez-Chacon Laboratory, Univ. de Sevilla, Spain.
Seminar at Chris DeZeeuw Laboratory, Erasmus University, Rotterdam, Netherlands.
Seminar at Ann Graybiel Laboratory, MIT, Boston, USA.

Symposium at the Locomotion and rhythmic mobility meeting, University P. et M. Curie, Paris.
Seminar at NPA lab, University P. and M. Curie, Paris, France.

Symposium on Neural basis of navigation, Cognivence Association, Paris, France.


Scientific Collaborations

2014-present Collaboration with Dr. Rui Costa (ERANET program partner, Champallimaud Institute, Lisbon, Portugal)
Anatomo-functional characterization of the hyperdirect pathway.

2013-present Collaboration with Dr. Nizar Ouarti (UPMC, ISIR, Paris, France)
Development of closed-loop stimulation technology

2013-present Collaboration with Dr. Brian Lau (ICM Institute, Paris, France)
Development of optogenetic and recording tools in rodent and monkeys

2013-present Collaboration with Dr. Phillipe Faure (UPMC, NPA, Paris, France)
Automated setup for high throughput behavioral acquisition system.

2009-present Collaboration with Pr. Ann Graybiel and Pr. G.. Feng (MIT, Cambridge, USA)
Ensemble neuronal recording and optogenetic in the SAPAP3-KO mouse model of OCD.

2002-2006 Collaboration with Pr. CI. DeZeeuw (Erasmus University, Rotterdam, Netherlands)
Experimental and theorical collaboration using the L7-PKCI transgenic mice.

2002-2006 Collaboration with Dr. A. Arleo (UPMC, Paris, France)
Computer tools analysis and theorical modelisation of behavioral results.

2004 Collaboration with Pr. L. Petrosini (IRCCS, Santa Lucia, Roma, Italy)
Experimental and theoretical collaboration on the role of cerebellum during navigation.