Our research is based on a confrontation between phenomenological and psychopathological studies of disorders involving the BG, using anatomical, behavioural, and physiological data.


Precise anatomical locations of both electrophysiological and imaging data, using an original histological 3D atlas, allow us to model the different circuits involved and their interactions. 


New therapeutic hypotheses are tested in parallel through clinical trials and animal experiments.


This research program is carried out in healthy human volunteers and in patients with Parkinson’s Disease, Tourette Syndrome, Obsessive-Compulsive Disorder, Depression, Cocaine Dependence, included in experimental clinical protocols that are promoted by institutional authorities (AP-HP, Inserm, CNRS) and agreed upon by local ethic committees.

Our main axes of research

  • Behavioral, electrophysiological and anatomical approaches of information processing in the subthalamic nucleus
  • Multiscale integration of electrophysiological recordings and atlas-based anatomy in the human basal ganglia
  • Exploration of repetitive behaviors in human and rodents combining experimental psychology, functional neuroimaging.
  • Therapeutic innovations:
    • Evaluation of new Cognitive Behavioral Therapy techniques using experimental paradigms
    • Development of innovative neurosurgical treatments using deep brain stimulation in neuropsychiatric diseases: Obsessive Compulsive Disorder (OCD), Tourette Syndrome, Depression
    • Evaluation of repetitive transcranial magnetic stimulation (rTMS) for Obsessive-Compulsive Disorder
    • Identification of electrophysiological biomarkers using optogenetics to develop closed loop stimulation strategy

Techniques used

  • Experimental psychology and functional neuroimaging;
  • Intracranial electrophysiological recordings of single-unit neuronal activity and local field potentials;
  • Three-dimensional (3D) atlas and high field anatomical MRI; diffusion-tensor imaging (DTI);
  • Voxel-based morphometry (VBM);
  • Development of imaging and stereotactic tools for DBS;
  • Multiscale integration of functional data and atlas-based anatomy in the human basal ganglia;
  • Transcranial magnetic stimulation (TMS);
  • Animal models and experimental therapeutics (rodents, primates);
  • Optogenetic approaches and design of new viral vector specifically targeting the hyperdirect pathway;
  • High throughput electrophysiological and behavioural acquisition system for animal models studies.

Notre équipe de recherche s’intéresse aux troubles mentaux qui impliquent les ganglions de la base (maladie de Parkinson,syndrome Gilles de la Tourette, trouble obsessionnel compulsif).Nous avons une approche multi-disciplinaire anatomique, comportementale et physiologique des aspects phénoménologiques et psychopathologiques de ces troubles.

Nous avons développé un atlas 3D histologique (une sorte de “carte du cerveau”) qui nous permet d’effectuer des localisations anatomiques précises d’après des données d’électrophysiologie et d’imagerie cérébrale afin de modéliser les différents circuits cérébraux et leurs interactions.

Nous testons de nouvelles hypothèses thérapeutiques par des expérimentations dans des modèles animaux. Enfin, nous développons et nous évaluons l’efficacité de nouvelles thérapies au moyen d’essais cliniques chez des patients.

Ce programme de recherche est mené grâce à la participation de volontaires sains et de de patients atteints de la maladie de Parkinson, du syndrome de Gilles de la Tourette, de trouble obsessionnel compulsif, de dépression, ou de dépendance à la cocaïne, tous inclus dans des protocoles de recherche clinique promus par les autorités institutionnelles (AP-HP, Inserm, CNRS) et soumis à l’approbation de comités d’éthique.