Anatomy and function of the hyperdirect pathway.
– I am dissecting the anatomical organisation of the frontal cortex to the subthalamic nucleus, using axonal tracing in macaque monkeys as well as high-resolution tractography in both monkeys and humans.
– The investigation of the functional significance of this pathway is performed through simultaneous recordings of cortical (MEG) and subthalamic (LFP) activities in obsessive compulsive patients undergoing deep brain stimulation surgery. Our working hypothesis is that it sets decisional thresholds.
Keywords : Hyperdirect pathway, subthalamic nucleus, decision-making, anatomy, tractography, electrophysiology